Advances in interventional therapy of malignant obstructive jaundice

Abstract

Malignant obstructive jaundice (MOJ) is a common clinical disease, in which a tumor presses the biliary stricture as the main reason to cause obstruction. Due to a lack of typical symptoms, MOJ usually has a low success rate of surgical resection and the prognosis is also poor. However, latest research from various prestigious labs nationally and internationally showed that percutaneous transhepatic biliary drainage (PTCD) and biliary stenting are the most effective methods for malignant obstructive jaundice. These methods can effectively relieve clinical symptoms, improve the liver function, and the quality of life of patients. PTCD combined with chemotherapy, 125Ⅰ seed implantation, radiofrequency ablation and other strategies targeting the primary tumors , can significantly prolong the patient’s survival, while active postoperative anti-infective therapy significantly reduced the complications. With the advent of new generations of anti-tumor drugs, interventional equipment and technology advances, the development of film stents and interventional therapy provides a variety of promising strategies and it is expected that patients with biliary stenting biliary patency, as will greatly extend the survival of patients. Key words: Obstructive jaundice; Percutaneous transhepatic cholangiography drainage; Interventional therapy; Review