Abstract
Hepatitis C virus (HCV), a blood-borne virus, is one of the leading causes responsible for chronic hepatitis, liver cirrhosis and even hepatocellular carcinoma. At present precise mechanism of HCV infection has not been known yet, and no effective treatment and vaccination against HCV are available. However, recent findings show that apart from the function of viral partial package as the nucleocapsid protein, HCV core protein also participates in modulating cell apoptosis, lipid metabolism, transcription and antigen presentation, and has a close relationship with interferon resistance. HCV core protein has intense trans-activation effect and its interaction with the host protein accounts for persistent infection and hepatocellular tumorigenesis. Further cognition and analysis of molecular features of HCV core protein is of significance to elucidate persist HBV infection, mechanism underlying tumorigenesis induced by HCV, as well as impact of HCV on hepatic steatosis and interferon resistance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
