Advances in experimental phasing.

Airlie J Mccoy,Thomas Schneider

doi:10.1107/s2059798316003375

Abstract

Advances in experimental phasing.

Highlights

This issue publishes the proceedings of the 2015 CCP4 Study Weekend on Advances in Experimental Phasing, held on 8–9 January 2015 at the East Midlands Conference Centre of the University of Nottingham, UK
A session on radiation damage was included to remind experimentalists of the unavoidable side effects of using X-rays for diffraction data collection, while a final session on evolving methods provided a forum for ideas for solving the phase problem employing unconventional approaches
The meeting began with a lecture by Neil Isaacs (University of Glasgow) sharing his personal view of the history of crystallographic phasing from the structure determination of zincblende, solved with the logic of constructive and destructive interference alone, via the heroic early macromolecular structure determinations by multiple isomorphous replacement, all the way to the routine exploitation of weak anomalous signals for the phasing of macromolecular crystals structures

Summary

Introduction

The meeting began with a lecture by Neil Isaacs (University of Glasgow) sharing his personal view of the history of crystallographic phasing from the structure determination of zincblende, solved with the logic of constructive and destructive interference alone, via the heroic early macromolecular structure determinations by multiple isomorphous replacement, all the way to the routine exploitation of weak anomalous signals for the phasing of macromolecular crystals structures. This issue publishes the proceedings of the 2015 CCP4 Study Weekend on Advances in Experimental Phasing, held on 8–9 January 2015 at the East Midlands Conference Centre of the University of Nottingham, UK.

Results

Conclusion