Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. PDAC is the fourth leading cause of death in the United States and Japan based on epidemiological data. Early detection of PDAC is very important to improve the prognosis of PDAC. Early detection of pancreatic ductal adenocarcinoma (PDAC) requires further examination after selecting cases with risk factors for the condition, such as family history, hereditary pancreatic carcinoma syndrome, intraductal papillary mucinous neoplasms, or chronic pancreatitis. The Japan Study Group on the Early Detection of Pancreatic Cancer has investigated and clarified the clinicopathological features for the early diagnosis of PDAC. In Japan, an algorithm for the early diagnosis of PDAC, which utilized the cooperation of local clinics and regional general hospitals, has been a breakthrough in the detection of early-stage PDAC. Further approaches for the early diagnosis of PDAC are warranted.
Highlights
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and the associated death toll continues to increase despite developments in treatment methods and diagnostic modalities [1,2]
Familial pancreatic carcinoma is defined as “PDAC arising in a family with two or more
Harinck et al revealed that magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS) played complementary roles in the detection of pancreatic lesions in patients at high risk for PDAC, including hereditary pancreatic carcinoma syndrome [14]
Summary
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and the associated death toll continues to increase despite developments in treatment methods and diagnostic modalities [1,2]. This is primarily due to the difficulty of diagnosing PDAC in its early stages. Several recent reports on early-stage PDAC have been published, and an improvement in prognosis for PDAC is expected. We present several approaches to diagnosing PDAC in its early stages
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