Abstract
Dermal stem cells(DSCs)have great proliferation and multidirectional differentiation potential. Keratinocytes can induce DSCs to migrate and differentiate into melanocytes by expressing Wnt-3a and E-cadherins. Researches have indicated that the generation of dermal and epidermal melanocytes is dependent on different signaling pathways. More concretely, epidermal melanocyte generation is highly dependent on the stem cell factor(SCF)signaling pathway, while dermal melanocyte generation on the endothelin 3(ET3)and hepatocyte growth factor(HGF)signaling pathways. The origin of nevus cells in pigmented nevus is not yet clear. Some studies suggest that nevus cells may derive from the stem cells which can differentiate into melanocytes. DSCs can differentiate into melanocytes, but further research is needed to determine whether they are the source of nevus cells. Key words: Melanocytes; Dermis; Signal transduction; Nevus, pigmented; Epidermis
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