Abstract
Treating bone defects coupled with pathogen infections poses a formidable challenge to clinical medicine. Thus, there is an urgent need to develop orthopedic implants that provide excellent antibacterial and osteogenic properties. Of the various types, copper-based biomaterials capable of both regenerating bone and fighting infections are an effective therapeutic strategy for bone tissue engineering and therefore have attracted significant research interest. This review examines the advantages of copper-based biomaterials for biological functions and introduces these materials’ antibacterial mechanisms. We summarize current knowledge about the application of copper-based biomaterials with antimicrobial and osteogenic properties in the prevention and treatment of bone infection and discuss their potential uses in the field of orthopedics. By examining both broad and in-depth research, this review functions as a practical guide to developing copper-based biomaterials and offers directions for possible future work.
Highlights
Bone tissue is a mineralized, viscous, elastic connective tissue that plays an important role in the human body (Kasugai, 2003)
We introduce the application of copper-based biomaterials with antibacterial and osteogenic properties in the prevention and treatment of bone infection
Many studies have shown that copper-based biomaterials have excellent antibacterial properties, angiogenesis and osteogenesis
Summary
Bone tissue is a mineralized, viscous, elastic connective tissue that plays an important role in the human body (Kasugai, 2003). This review focuses on the application of copper combined with biomaterials in bone tissue and the associated antibacterial mechanisms. We introduce the application of copper-based biomaterials with antibacterial and osteogenic properties in the prevention and treatment of bone infection.
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