Abstract
HIV-1 is the causative agent of acquired immunodeficiency syndrome (AIDS). It affects millions of people worldwide and the pandemic persists despite the implementation of highly active antiretroviral therapy. A wide spectrum of techniques has been implemented in order to diagnose and monitor AIDS progression over the years. Besides the conventional approaches, microfluidics has provided useful methods for monitoring HIV-1 infection. In this review, we introduce continuous microfluidics as well as the fabrication and handling of microfluidic chips. We provide a review of the different applications of continuous microfluidics in AIDS diagnosis and progression and in the basic study of the HIV-1 life cycle.
Highlights
The replication cycle ends with the release of new viral particles, which proceed to the last maturation step to be infectious
A magnet is placed underneath the chip and only the target templates with the magnetic ligation products flow along the channel and will be collected in the outlet well to be detected by a fluorometer
Microfluidics has revolutionized the fields of biology and health by offering the possibility of managing biological samples in tiny channels and chambers
Summary
Microfluidics is the science of manipulating and controlling fluids, usually in the range of microliters. Itand is used to create of finefabrication features that work through an optical process, built layer on layer This technology allows the integration of human tissue into a technique in biological research. It is used to create fine features that work through an Besides the traditional microfluidic devices that are fabricated using PDMS or other polymers optical process, built layer on layer. This technology allows the integration of human tissue into a and plastics, microfluidic devices can be fashioned from paper. Paper-based devices are miniaturized device in order to mimic its microenvironment [15].and low cost, since no pump is especially used in developing countries due to their availability required for fluid transport (passive transport).
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