Abstract
Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases.Objective: In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers.Conclusion: CHD proteins play a crucial role in stem cell differentiation and human diseases.
Highlights
OF chromodomain helicase DNA-binding (CHD) SUPERFAMILYThere are three classes of epigenetic modifier proteins, including chromatin writers, erasers, and readers
In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers
CHD proteins play a crucial role in stem cell differentiation and human diseases
Summary
Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
