Abstract
The role of chemotherapy in the management of head and neck squamous cell cancers continues to evolve. Concurrent chemotherapy and radiation represents a standard treatment option for organ preservation in larynx and hypopharynx squamous cell carcinomas, unresectable locally advanced head and neck cancer, nasopharyngeal cancer, and post-operative therapy of high-risk resected disease. Chemotherapeutic agents and their combinations have known activity in metastatic disease and are frequently used for palliation. Emerging therapeutic approaches have been fueled by the observed shift in the pattern of disease recurrence after definitive therapy and the development of molecular targeted agents with disease activity. The recognition of human papillomavirus-associated oropharyngeal squamous cell carcinoma as a distinct clinical entity among head and neck cancers will influence the design of future clinical investigation.
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