Abstract
The review collects together some recent information on the identity and pharmacological properties of magnoflorine, a quaternary aporphine alkaloid, that is widely distributed within the representatives of several botanical families like Berberidaceae, Magnoliaceae, Papaveraceae, or Menispermaceae. Several findings published in the scientific publications mention its application in the treatment of a wide spectrum of diseases including inflammatory ones, allergies, hypertension, osteoporosis, bacterial, viral and fungal infections, and some civilization diseases like cancer, obesity, diabetes, dementia, or depression. The pharmacokinetics and perspectives on its introduction to therapeutic strategies will also be discussed.
Highlights
Natural products that contain a nitrogen atom in their structure, generally called alkaloids, belong to the most active metabolites of natural origin that have been extensively used as toxins and drugs throughout the history
Among several classes of these compounds, which are derived from different aminoacids in their biochemical synthesis pathways, the isoquinoline alkaloids constitute the largest and the most differentiated group that has been divided into several classes [1]
To confirm that free-radical scavenging properties depend on the number and position of −OH groups, MGN isolated from Epimedium elatum was again tested in a diphenyl-1-picrylhydrazyl radical (DPPH) assay
Summary
Natural products that contain a nitrogen atom in their structure, generally called alkaloids, belong to the most active metabolites of natural origin that have been extensively used as toxins and drugs throughout the history. Magnoflorine has been of particular interest to the authors of this review. Magnoflorine (MGN) can be perceived as an underestimated secondary metabolite, even if it is widely distributed among various plant representatives. Several scientific manuscripts investigate the pharmacological potential of this alkaloid and determine its presence in both plant extracts and biological samples. The aim of the review was to collect the pharmacological properties of MGN, which have been proven and described in the scientific manuscripts over the period of last three decades, and to draw the researchers’ attention to this molecule, which exhibits an interesting pharmacological potential
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