Abstract
Advances in bovine immunology - new tools and new insights to tackle old foes.
Highlights
The publication of the bovine genome in 2009 and the advent of new high-throughput technologies have facilitated a massive expansion in our knowledge of the immune response in cattle
McLoughlin et al used multi-dimensional scaling to unambiguously classify peripheral blood leukocyte transcriptomic profiles from Mycobacterium bovis infected and healthy cattle, thereby uncovering potential biomarkers for M. bovis infection [4]. This technology is a powerful tool for unraveling the complexities of host immune response and provides new layers of information, which deepens our understanding of host–pathogen interactions that underlie Mycobacterial disease pathogenesis
The macrophage is recognized as the key effector cell driving antimycobacterial immunity but which can be hijacked by mycobacteria, thereby contributing to suboptimal bacterial clearance and disease chronicity
Summary
The publication of the bovine genome in 2009 and the advent of new high-throughput technologies have facilitated a massive expansion in our knowledge of the immune response in cattle. The advent of Next-Generation Sequencing (NGS) technologies holds significant promise to overcome limitations in current generation test sensitivity and specificity and as discussed by McLoughlin et al, transcript biomarker signatures have been identified, which discriminate between TB patients with active and latent disease.
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