Abstract
Understanding the fundamentals of natural design, structure, and function has pushed the limits of current knowledge and has enabled us to transfer knowledge from the bench to the market as a product. In particular, biomimicry―one of the crucial strategies in this respect―has allowed researchers to tackle major challenges in the disciplines of engineering, biology, physics, materials science, and medicine. It has an enormous impact on these fields with pivotal applications, which are not limited to the applications of biocompatible tooth implants, programmable drug delivery systems, biocompatible tissue scaffolds, organ-on-a-chip systems, wearable platforms, molecularly imprinted polymers (MIPs), and smart biosensors. Among them, MIPs provide a versatile strategy to imitate the procedure of molecular recognition precisely, creating structural fingerprint replicas of molecules for biorecognition studies. Owing to their affordability, easy-to-fabricate/use features, stability, specificity, and multiplexing capabilities, host-guest recognition systems have largely benefitted from the MIP strategy. This review article is structured with four major points: (i) determining the requirement of biomimetic systems and denoting multiple examples in this manner; (ii) introducing the molecular imprinting method and reviewing recent literature to elaborate the power and impact of MIPs on a variety of scientific and industrial fields; (iii) exemplifying the MIP-integrated systems, i.e., chromatographic systems, lab-on-a-chip systems, and sensor systems; and (iv) closing remarks.
Highlights
Biological, chemical, and physical phenomenological events have always been of interest in various fields of fundamental and applied research
Three dimensional-biomimetic cavities complementary template molecule in shape, physical, and chemical functionality can becan produced by creating to the template molecule in size, shape, size, physical, and chemical functionality be produced by a creating matrix around the around template molecules
InCombination this review, we state how natural information could be translated into a biomimetic system
Summary
Biological, chemical, and physical phenomenological events have always been of interest in various fields of fundamental and applied research. These bioinspired systems are adaptable and inventive, and mimic the natural components of the body [18] The latter approach, i.e., the bioreceptor-mimicking strategy, aims to replicate the molecular architecture of bioreceptor molecules, opening new avenues in the field of recognition-stemmed platforms, such as sensors, diagnostics, and chromatography. In this context, one of the most crucial bioinspired systems, dubbed molecularly imprinted polymer-based systems, supply a wide range of versatile features, used to imprint target molecules with different molecular weights, sizes, structures, and chemical and physical properties [19,20]. Four major points were addressed: the requirement of biomimetic systems, the description and advances of the molecular imprinting method; the recent reports of the molecularly imprinted polymer-integrated systems from the last three years; and a statement of closing remarks
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