Advances in Asymmetric N Construction of Metal and Organic Small Molecules

Abstract

Lot of natural products, pharmaceuticals and functional materials with chiral amines do many useful job, and this group also a valuable constituents of versatile building blocks and important chiral catalysts as well as chiral auxiliaries in organic synthesis. Therefore, to develop efficient methods for the synthesis of structurally diverse chiral amines and chiral amine scaffolds has great importance and huge application vaule. symmetric catalysis is the most efficient method to synthesize chiral organic molecules. Cooperatively catalyzed by transition metal and small organic molecules can be used to simultaneously or continuously activates the bonds and rebuild, it can help some reaction which can not happen with only one catalyst to move on. This article reviews some cases of chiral nitrogen formation through metal catalysis, organic small molecule catalysis and their synergistic catalysis, and briefly discusses the challenges and future development directions in this area.