Advances in Analyses of Profens in Biological and Environmental Samples by Liquid Chromatography

Abstract

Profens (aryl propionic acid) are non-steroidal anti-inflammatory drugs. These are broadly used for treating swelling, arthritis and fever. This article presents the comprehensive ordinary and enantioselective analyses of the profens by liquid chromatography. Liquid-liquid extraction, solid phase extraction, solid phase micro-extraction and other sample preparation techniques have been discussed. Most widely used high-performance liquid chromatographic columns are of octadecyl silica gels for ordinary analyses and polysaccharides and cyclodextrins for the enantioselective analyses. Many normal and reversed mobile phases have been used. The profens analyses are discussed in the biological and water samples and pharmaceuticals formulations. The optimization strategies, recent trends in the analyses, future challenges and prospectives have also been discussed. Keywords: Biological and environmental samples, future challenges and prospectives, high-performance liquid chromatography, ordinary and enantioselective analyses, profens, toxicities.