Year-end Sale % OFF 
Abstract
Metabolomics and exposomics are important in the studies of human health and diseases. Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only improve sensitivity but also bring significant benefits for selectivity, accuracy, omics coverage, and analysis throughput. Therefore, MS-based CIL techniques have been increasingly used in metabolome and exposome analysis. In this review, we summarize the advantages of MS-based CIL techniques in sensitivity, accuracy, selectivity, stability, analysis throughput, and applicability, and also discuss the potential shortcomings. Moreover, based on five subgroups of representative metabolites and xenobiotics containing amino, carboxyl, carbonyl, hydroxyl and sulfhydryl groups, we review the advances of MS-based CIL techniques in targeted and not-targeted analysis. Notably, some novel CIL techniques emerged in the structural design of CIL reagents has also discussed. Finally, we give our perspective on the future of MS-based CIL techniques in this field, especially on the structural design of ideal CIL reagents.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
