Abstract
Prof Peter van de Kerkhof, Radboud University Nijmegen Medical Centre, the Netherlands, discussed the very long history, particularly in Germany and the Netherlands, of dimethyl fumarate (a fumaric acid ester [DMF]) in treating psoriasis in adults. However, only recently, with a new DMF product registration in Europe, has clinical research escalated to investigate the most effective clinical use of this agent. Treatment strategies in patients with psoriasis should be personalised, with considerations of the disease, patient characteristics and preferences, as well as current and historical treatments. He presented a case scenario to highlight which patients might benefit most from DMF as a first-line systemic treatment for moderate-to-severe psoriasis. He further discussed the role of acitretin (a synthesised retinoic acid) as monotherapy in pustular psoriasis and erythrodermic psoriasis, and in combination for chronic plaque psoriasis. He concluded that in patients requiring systemic therapy with contraindications for immunosuppressive therapies, DMF and acitretin may provide a unique profile and treatment solution.
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