Abstract
The Minisci reaction, which encompasses the radical C-H alkylation of heteroarenes, has undergone revolutionary development in recent years. The application of photoredox catalysis for alkyl radical generation has given rise to a multitude of methods that feature enhanced functional group tolerance, generality, and operational simplicity. The intent of this short review is to bring readers up to date on this rapidly expanding field. Specifically, we will highlight key examples of visible light-driven Minisci alkylation strategies that represent key advancements in this area of research. The scope and limitation of these transformations will be discussed, with a focus on examining the underlying pathways for alkyl radical generation. Our goal is to make this short review a stepping stone for further synthetic research development.
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