Advancements in Glioblastoma Management: A Comprehensive Review of Therapeutic Strategies and Future Directions

Abstract

Glioblastoma, the most aggressive and lethal primary brain tumor, presents a formidable challenge to clinicians and researchers alike. This article provides a comprehensive overview of the latest developments in the management of glioblastoma, focusing on therapeutic strategies and emerging directions for improved patient outcomes. The aggressive nature of glioblastoma calls for a multifaceted approach, and this review examines the current state of surgical, radiotherapeutic, and chemotherapeutic interventions. Furthermore, we explore the promising avenues of targeted therapies, immunotherapy, and the role of precision medicine in tailoring treatment for individual patients. Additionally, we discuss the challenges of overcoming treatment resistance, the potential of combining modalities, and the impact of genetic and molecular profiling. This article serves as a critical resource for clinicians, researchers, and policymakers involved in the ongoing battle against glioblastoma, shedding light on the evolving landscape of glioblastoma management