Abstract
This review gives a brief description on the skin and its essential functions, damages or injury which are common to the skin and the role of skin substitute to replace the functions of the skin soon after an injury. Skin substitutes have crucial role in the management of deep dermal and full thickness wounds. At present, there is no skin substitute in the market that can replace all the functions of skin ‘and the research is still continuing for a better alternative. This review is an attempt to recollect and report the past efforts including skin grafting and recent trends like use of bioengineered smart skin substitutes in wound care. Incorporation functional moieties like antimicrobials and wound healing agents are also described.
Highlights
Skin is the largest organ of the body with many essential functions that would help the survival
Methodology and materials used in the care of both acute and chronic wounds have attained a new pace and direction
Cultured epithelial autografts and tissueengineered grafts were developed as a part of the growing interest in the field of skin regeneration upon healing
Summary
Advancement of wound care from grafts to bioengineered smart skin substitutes Robin Augustine Nandakumar Kalarikkal Sabu Thomas. This article is published with open access at Springerlink.com
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