Advancement of Targeted Drug Delivery Over Conventional Drug Delivery System Targeting to Colonic Region

Abstract

Colon-targeted drug delivery is a wonderful drug delivery system targeting the lower parts of the GI tract to treat several colonic diseases such as inflammatory bowel diseases subdivided as ulcerative colitis, Crohn’s disease, amoebiasis, chronic diarrhea, colon cancer, vaginal infection, and bacterial infections, etc. A conventional drug delivery system can be referred to as a release of the drug, particularly to the targeted organ with a predetermined rate in a controlled manner. To achieve the prolonged therapeutic effect with predictable drug release kinetics, reduction of fluctuation in the steady-state concentration, increasing the therapeutic efficacy that convenient to patient and reduction of the patient compliance. Conventional drug delivery systems have some disadvantages which can be overcome by target-specific drug delivery systems. A targeted drug delivery system is a wonderful approach to target the pharmacological and therapeutical active moiety to target a specific region, and not to target non-targeted areas such as organ or tissue and accumulate to the targeting region only to show pharmacological activities. Some important criteria can be noticed under targeted drug delivery such as they are selectively and effectively targeting local as well as systemic regions and also involved in the pre-identified target can be set to deliver the active moiety, increase or enhancement of therapeutic concentration at the targeting region and accumulation of the active moiety to the target region and show high concentration, targeted drug delivery can enhancement of therapeutic activity with less adverse effect with less adverse events. The review discusses the advancement of targeted drug delivery over conventional drug delivery targeting the colonic environment to treat colonic diseases.