Abstract
Abdominal aortic aneurysm (AAA) is a cardiovascular disease with a high risk of death, seriously threatening the life and health of people. The specific pathogenesis of AAA is still not fully understood. In recent years, researchers have found that amino acid, lipid, and carbohydrate metabolism disorders play important roles in the occurrence and development of AAA. This review is aimed to summarize the latest research progress of the relationship between AAA progression and body metabolism. The body metabolism is closely related to the occurrence and development of AAA. It is necessary to further investigate the pathogenesis of AAA from the perspective of metabolism to provide theoretical basis for AAA diagnosis and drug development.
Highlights
Abdominal aortic aneurysm (AAA) is a disease in which the abdominal aorta gradually expands like a tumor under the action of blood pressure
Previous studies have found that the pathological process of AAA mainly includes local inflammatory cell infiltration, protease hydrolysis of elastic fibers and collagen fibers, vascular smooth muscle cell (VSMC) apoptosis and phenotypic transformation, and oxidative stress caused by oxidation and anti-oxidation imbalance [1, 2, 5]
Clinical studies found that HHcy caused by congenital CBS deficiency would increase the risk of vascular diseases, such as abdominal aortic aneurysm, pulmonary embolism, and myocardial infarction, and lowering of circulating Hcy level by long-term treatment can significantly improve the vascular outcome of patients with CBS deficiency [9, 10]
Summary
Specialty section: This article was submitted to Cardiovascular Metabolism, a section of the journal Frontiers in Cardiovascular Medicine. Research of Abdominal Aortic Aneurysms on Metabolism. Abdominal aortic aneurysm (AAA) is a cardiovascular disease with a high risk of death, seriously threatening the life and health of people. The specific pathogenesis of AAA is still not fully understood. Researchers have found that amino acid, lipid, and carbohydrate metabolism disorders play important roles in the occurrence and development of AAA. This review is aimed to summarize the latest research progress of the relationship between AAA progression and body metabolism. The body metabolism is closely related to the occurrence and development of AAA. It is necessary to further investigate the pathogenesis of AAA from the perspective of metabolism to provide theoretical basis for AAA diagnosis and drug development
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