Abstract
Chemotherapy is one of the important means of tumor therapy. However, most of the anti-tumor drugs that currently used in clinic are hydrophobic non-specific drugs, which seriously affect the efficacy of drugs. With the development of nanotechnology, drug efficacy can be improved by selecting appropriate biodegradable nanocarriers for achieving the controlled release, targeting and higher bioavailability of drugs. This paper reviewed the research progress of anti-tumor drug nanoparticle carriers, which mainly summarized the materials used for anti-tumor drug nanoparticle carriers and their effects in anti-tumor drugs, as well as the targeted drug delivery methods of anti-tumor drugs based on nanocarriers.
Highlights
Tumor is still one of the main fatal diseases of human beings, and chemotherapy is one of the main methods to treat tumor in clinic [1]
Traditional chemotherapy drugs can kill tumor cells with high efficiency, they have toxic and side effects on normal tissues due to their lack of specificity while nanotechnology provides a new opportunity for tumor targeted therapy [43]
Redox-responsive nanocarriers can intelligently target drug release in tumor cells by introducing disulfide or diselenide bonds [78], which is of great significance to many drug molecules (e. g. camptothecin, doxorubicin, etc.) that exert their effects in the organelles of tumor cells
Summary
Tumor is still one of the main fatal diseases of human beings, and chemotherapy is one of the main methods to treat tumor in clinic [1]. The nanoparticles used as anti-tumor drug loading system have a size of 1–100 nm [4] and mainly include nano-liposomes, nano-polymers, nano-gene carriers, nano-inorganic materials and other drug carriers. Reduce drug resistance and improve anti-cancer effect
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