Advanced MRI view into the central mechanisms of migraine

Abstract

Since migraine is primarily a disorder of brain function and excitability, functional MRI (fMRI) studies represent a powerful tool to explore central nervous system correlates in migraine. In this frame, fMRI investigations fall into two main categories, specifically the event-related and the resting state ones, exploring respectively the brain activity in response to tasks and the connectivity of specific brain areas or networks at rest. The latter relays on several methodological approaches such as seed-based analysis, independent component analysis (ICA) and graph theory-based analysis.