Abstract
Drug nanosuspensions/nanocrystals have been recognized as one useful and successful approach for drug delivery. Drug nanocrystals could be further decorated to possess extended functions (such as controlled release) and designed for special in vivo applications (such as drug tracking), which make best use of the advantages of drug nanocrystals. A lot of novel and advanced size reduction methods have been invented recently for special drug deliveries. In addition, some novel downstream processes have been combined with nanosuspensions, which have highly broadened its application areas (such as targeting) besides traditional routes. A large number of recent research publication regarding as nanocrystals focuses on above mentioned aspects, which have widely attracted attention. This review will focus on the recent development of nanocrystals and give an overview of regarding modification of nanocrystal by some new approaches for tailor-made drug delivery.
Highlights
Drug nanosuspensions, often referred to as drug nanocrystals, can be considered as one of the most successful pharmaceutical nanotechnology approach
An increasing number of novel advanced preparation methods and downstream technologies have been developed for tailor-made drug delivery
The Wet bead milling (WBM) led to the smallest particle size of 88 nm as well the highest final drug release, tablets produced applying nanocrystals obtained from high pressure homogenization (HPH) and the two step approach could achieve faster dissolution rates within the first 20 min than WBM (Liu et al, 2018)
Summary
Often referred to as drug nanocrystals, can be considered as one of the most successful pharmaceutical nanotechnology approach. Some novel technologies have been invented recently, which possessed the capability to produce smaller nanoparticle sizes
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