Abstract
Metal-organic frameworks (MOFs) are porous crystalline polymers composed of coordination reactions between organic ligands and metal ions. They have high loading capacity, high specific surface area, high flexibility and a variety of different material preparation options. In different fields, MOFs also play different roles. It has been employed as a promising material for efficient drug delivery systems due to its unique characteristic and structures. This paper discusses the application of nanoscale MOFs (NMOFs) in the field of drug delivery and introduces its advantages and disadvantages compared with traditional DDSs materials, as well as different methods used as carriers for different therapeutic gases (CO, NO, O2), thereby achieve targeted delivery of drugs. The different biological toxicity, structural stability, morphology under physiological conditions, and control of pore channels caused by different metal linkers and organic ligands are studied and analyzed, which provides the future development of new drug-carrying systems and MOFs in other drug fields. Insights and guidance.
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