Abstract
Background: Malaria is a leading cause of death in sub-Sahara Africa including Nigeria. The oxidative stress associated with malaria infection may affect the plasma protective proteins and trace elements which participate in the antioxidant defensive system. Aim: The aim of this study was to assess the Advanced Metallothionein Profile (AMP) of malaria infected children in Benin metropolis and determine its association with parasite density. Methods: This case-control study had a total of 350 children between 6 months and 11 years with two hundred malaria positive children as case and 150 malaria negative children as control. Socio-demographic data was obtained through a semi-structured questionnaire. Blood samples were taken from participants to determine malaria parasite density using thick film microscopy. Serum Metallothionein (MT), Glutathione (GSH) and Ceruloplasmin (CP) were analyzed using Enzyme linked Immunosorbent assay (ELISA) techniques, while copper (Cu) and Zinc (Zn) levels were determined using Atomic Absorption spectrometry (AAS). The data were analyzed using appropriate statistical tools.
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