Abstract
Advanced glycation endproducts (AGEs) are hypothesized to contribute to the development of type 2 diabetes and related complications. Previous studies used antibody-based methods to quantify circulating levels of glycated proteins. However, data based on more precise and more specific liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based measurements of these glucose-amino acid adducts are rare and limited to subjects with known diabetes. Thus we aimed to compare plasma AGE levels of individuals with and without impaired glucose metabolism (IGM) and to correlate AGE levels with fasting glucose, fasting insulin and the HOMA-IR index as a surrogate marker of insulin resistance.
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