Abstract
Advanced glycation end products (AGEs) are chemical modifications of proteins by nonenzymatic Maillard reaction.The formation and accumulation of AGEs have been known to be accelerated when suffered from diabetes.Combinations of AGEs and their receptors (RAGE) cause oxidative stress and inflammation,which result in functional alterations of osteoblasts,osteoclasts and bone mesenchymal stem cells.On the other hand,overcrossslinking of AGEs and collagen can also cause loss of flexibility and elasticity and increase brittleness of bone.Accordingly,AGEs play an crucial role in the development of diabetic osteoporosis.Measurement of serum and urinary AGEs composition can be effective for predicting diabetic osteoporosis. Key words: Diabetic osteoporosis; Advanced glycation end products; Bone remodeling
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
