Advanced coordination polymer materials for drug delivery systems

Abstract

Coordination polymers demonstrated outstanding performance and ability in drug delivery resulting from their porosity and combinatory structure of non-metal and metal. Previous research has made considerable efforts on different aspects of coordination polymers, including synthesises, modifications and pre-clinical studies. Furthermore, among those coordination polymers, metal organic frameworks turn out to be the one that performs best. Therefore, recent researches are more and more inclined to using MOFs as drug delivery systems. This literature review will talk about the current synthesis methodologies of coordination polymers (especially MOFs) and the drug delivery using coordination polymers bulk system, nano-scale coordination polymers system and nano-scale coordination colloids system. Specifically, the mechanisms and the properties of the synthesizing methods and drug delivery systems. This review will conclude the current development of coordination polymers used as drug delivery systems and the newest synthesized approaches. At the same time, the review will also make an outlook towards the future development of the coordination polymers drug delivery systems.