Abstract
We have summarized diverse synthetic approaches for the modification of peptides by employing transition-metal-catalyzed reactions. These methods can deliver unusual peptides suitable for peptidomimetics. To this end, several popular reactions such as Diels–Alder, 1,3-dipolar cycloaddition, [2+2+2] cyclotrimerization, metathesis, Suzuki–Miyaura cross-coupling, and Negishi coupling have been used to assemble modified peptides by post-assembly chemical modification strategies. 1 Introduction 2 Synthesis of a Cyclic α-Amino Acid Derivative via a Ring-Closing Metathesis Protocol 3 Peptide Modification Using a Ring-Closing Metathesis Strategy 4 Peptide Modification via a [2+2+2] Cyclotrimerization Reaction 5 Peptide Modification by Using [2+2+2] Cyclotrimerization and Suzuki Coupling 6 Peptide Modification via a Suzuki–Miyaura Cross-Coupling 7 Peptide Modification via Cross-Enyne Metathesis and a Diels–Alder Reaction as Key Steps 8 Peptide Modification via 1,3-Dipolar Cycloaddition Reactions 9 Modified Peptides via Negishi Coupling 10 A Modified Dipeptide via Ethyl Isocyanoacetate 11 Conclusions
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.