Abstract
Mycobacterium is a kind of spirited, poisonous, infectious pathogens. Tuberculosis caused by mycobacteria is extremely difficult to cure and these commonused antibiotic drugs are not clinically effective.The reason could be explained as follows: the pathogens escape from the fusion destruction of macrophage lysosomes through a series of unclear immune escape mechanism, and then survive and be parasitic in the phagosome of macrophage. A series of valuable achievements which mainly focus on the formation of SNARE complex, the role of Rab7, Rab5 and its effect protein EEA-1 in the maturation of late endosome, the role of autophagy in the immune escape mechanism have been published these year. It is important to clarify the role of Mycobacteria in immune escape. Key words: Mycobacteria; Lysosome; Immune escape
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