Advance in research on the relationship between mammalian target of rapamycin signaling pathway and ophthalmic diseases

Abstract

Mammalian target of rapamycin (mTOR) is a highly evolutionary conserved protein kinase and plays a critical role in the regulation of cell growth, growth factors and cell energy, and thus contributes to the formation of nutrition, metabolism and aging processes.Recent studies found that mTOR signaling pathway is associated with cell cycle, protein synthesis and metabolism, and it is an important pathway of diseases such as development of tumor, metabolic disorders, nervous system disease and inflammation.The relationship between mTOR signaling pathway and ophthalmic diseases was reviewed in this article. Key words: Mammalian target of rapamycin; Signaling pathway; Rapamycin; Ophthalmic diseases