Advance in research on the function of antigen presenting cellsregulated by autophagy

Abstract

Objective This present study was to detect the role of IL-17A on the correlation between chronic periodontitis(CP) and rheumatoid arthritis(RA).Methods According to the inclusion criteria selected 85 subjects were detected into four groups:①20 patients with chronic periodontitis;②23 patients with the RA;②26 patients with CP and RA;④16 healthy numbers as the control group.The clinical periodontal parameters including probing depth (PD),clinical attachment loss(CA L),and bleeding index(BI) were examined,and the serum and GCF levels of IL-17A were measured by enzyme-linked immunosorbent assay(ELISA).Results The IL-17A levels in serum of patients with CP and RA[(2216.0 ± 1520.87)pg/mL]were significantly higher than the RA group [(851.59 ± 975.81) pg/mL],CP group [(1039.7 ± 1004.83) pg/mL] and the control group[(209.48 ± 50.02)pg/mL].Serum levels of IL-17A in CP group and RA group were significantly higher than the healthy control group(P ＜0.05).The IL-17A levels in GCF of in the HP group[(356.75 ±69.07)pg/mL],RA group[(381.08 ± 79.48) pg/mL]/CP group [(397.82 ± 108.53) pg/mL] and patients with CP and RA[(414.71 ± 103.09)pg/mL] showed a trend of increase,but no statistical difference (P ＞0.05).Conclusions IL-17A may have some significance in the study of the correlation between chronic periodontitis and rheumatoid arthritis. Key words: Interleukin-17A; Chronic periodontitis; Rheumatoid arthritis