Abstract
p53 upregulated modulator of apoptosis(PUMA) is a recently identified p53 target gene which can induce apoptosis.Compared with other p53 target genes,p53 has two important characteristics.One is that PUMA almost mediates all p53-dependent apoptotic signals.The other is that PUMA is not only required for p53-dependent apoptotic pathway,but also for p53-independent apoptotic pathway.That means although PUMA is p53 target gene,it is also necessary for p53-independent apoptosis.In cardiomyocytes,PUMA is involved in apoptosis induced by various stimulations such as ischemia/reperfusion,endoplasmic reticulum stress.Therefore,PUMA plays a pivotal role in cardiomyocyte apoptosis.
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