Abstract
Background O-linked attachment of the monosaccharide-N -acetylglucosamine(O-GlcNAc) is a highly dynamic and ubiquitous posttranslational protein modification, plays a critical role in regulating numerous biological processes. O -GlcNAc transferase and O-GlcNAcase are responsible for the addition and removal of O-GlcNAc from serine/threonine residues, respectively. Objective To review the potential mechanisms of O -GlcNAc modification and the target protein. Content Main potential mechanisms of O-GlcNAc modification include antagonizing inflammatory, increasing synthesis of HSPs, inhibiting apoptosis, etc. Trend Further insights into the signal pathway of O -GlcNAc modification may provide a nice prospect for the therapy of cardiovascular dysfunction. Key words: O-GlcNAc modification; Cardiovascular protection; Anti-inflammatory; Heat shock proteins; Anti-apoptosis
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