Abstract

Cathepsin K is a lysosomal cysteine protease of the papain superfamily.Recently,Cathepsin K was found as an intracellular protease in lysosome and it is one of the capital enzymes for extracellular matrix degradation.Gathepsin K is not only correlated with normal physiological regulation of human body,which expressed in osteoclasts,involved in bone remodeling and resorption,and play a vital role in chondrocyte extracellular matrix degradation,but also abnormally expressed in many solid tumors.This review summarizes the functions of CTSK gene and its association with tumors and other diseases. Key words: Cathepsin K; Tumor

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