Advance in Helicobacter pylori resistance to clarithromycin

Abstract

Helicobacter pylori (H pylori) infection is the main cause of chronic active gastritis and peptic ulcer disease, and studies indicated eradication of H pylori could promote the healing of peptic ulcer. H pylori resistance to clarithromycin, which shows an increasing tendency year by year, is related with mutations of H pylori 23S rRNA domain V. Molecular mechanism and detection technology of H pylori resistance to clarithromycin have become the focus of current researches. Investigations on H pylori resistance to antibiotics are of great significance for the diagnosis and therapy of H pylori infection.