Abstract
The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing quickly. However, the current clinical approaches to sarcopenia are limited. Recently, novel drug delivery systems offer new possibilities for treating aged muscle loss. Herein, we briefly recapitulate the potential therapeutic targets of aged skeletal muscle and provide a concise advance in the drug delivery systems, mainly focus on the use of nano-carriers. Furthermore, we elaborately discuss the prospect of aged skeletal muscle treatment by nanotechnology approaches.
Highlights
Advance in Drug Delivery for Ageing Skeletal MuscleYi Li 1,2†, Ming Chen 1,2†, Yanpeng Zhao 1,2, Ming Li 1,2, Yong Qin 3, Shi Cheng 3, Yanyu Yang 4*, Pengbin Yin 1,2*, Licheng Zhang 1,2* and Peifu Tang 1,2
Skeletal muscles, as one of the largest organs in the body, are characterized by their mechanical activity required for posture, movement, and breathing (Fan et al, 2013; Pedersen, 2013)
A phase 2 randomized study involved 170 aged women diagnosed with sarcopenia and moderate physical dysfunction showed a significant increase in lean body mass but fail to improve muscle strength or function after receiving MK-0773, the selective androgen receptor modulator (SARM) (Papanicolaou et al, 2013)
Summary
Yi Li 1,2†, Ming Chen 1,2†, Yanpeng Zhao 1,2, Ming Li 1,2, Yong Qin 3, Shi Cheng 3, Yanyu Yang 4*, Pengbin Yin 1,2*, Licheng Zhang 1,2* and Peifu Tang 1,2. Tang P (2020) Advance in Drug Delivery for Ageing Skeletal Muscle. The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing quickly. Novel drug delivery systems offer new possibilities for treating aged muscle loss. We briefly recapitulate the potential therapeutic targets of aged skeletal muscle and provide a concise advance in the drug delivery systems, mainly focus on the use of nanocarriers.
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