Abstract
Granulosa cell tumors is classified into juvenile and adult types and comprise less than 5% of ovarian tumors in women and are much rarer in men which only 45 have been previously reported. We report here a 40-year young man with a left testicular adult type granulosa cell tumor. The tumor measured 5.5X5X4cm; Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin. Post operative CT scans shows a lomboaortic lymphnodes treated by four cycles of chemotherapy type BEP (bleomycin, etoposide, cisplatin). The thoraco abdominal CT scans post chemotherapy shows the disappearance of the right testicular nodule and the lomboaortic lymphnodes. 2 years after treatment, the patient is alive and well with no signs of recurrence. Our report highlights one more case of this very rare tumor of the testis, which is quite problematic In terms of prognosis and management, and for this reason seems to have attracted the interest of many researchers recently.
Highlights
Granulosa cell tumor (GST) belongs to the sex-cord/stromal tumors of the gonads [1]
We report an original case of adult type granulosa cell tumor in the testis reported for the first time at Mohamed VI center for cancer treatment in Casablanca for the first time and briefly review the previously published literature so as to improve the quality of management of this affection
These findings strongly suggest the diagnosis of a granulosa cell tumor
Summary
Granulosa cell tumor (GST) belongs to the sex-cord/stromal tumors of the gonads [1]. Two forms of GST have been recognized, namely, the typical adult type, and its variation, and the juvenile type [1]. Beta-hCG, and LDH were within normal ranges He underwent inguinal surgical exploration of the left testis in June 2013, when a large testicular mass was found. Immunohistochemical tests were positive for inhibine and vimentin, but negative for epithelial membrane antigen These findings strongly suggest the diagnosis of a granulosa cell tumor. His post operative blood tests were within normal limits, and the post operative abdominal and thoracic CT scans shows a right testis swollen with presence of nodules on the path of the left spermatic cord associated with a lomboaortic lymphnodes (Figure 1, Figure 2, Figure 3).the patient underwent 4 cycles of chemotherapy type BEP (bleomycin, etoposide,cisplatin).The abdominal and thoracic CT scans post chemotherapy shows the disappearance of the right testicular nodule and the lomboaortic lymphnodes. No signs of recurrence or metastasis have been identified after 6 months of follow-up
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