Abstract
Objective: To evaluate the clinicopathological features, outcomes and prognostic factors affecting the disease-free interval in women with adult-type granulosa cell tumor.Methods: A retrospective descriptive study of patients with adult-type granulosa cell tumors of the ovary (AGCTs) during January 2001 to October 2016 were recruited. The data record of all patients was analyzed to determine clinic-pathological features, treatment, survival, and prognostic factors.Results: Eighteen women with adult-type granulosa cell tumors (AGCTs) were diagnosed. The mean age+ SD was 48.72+ 5.95 years. The adnexal mass was the most common presenting symptoms (83.3%) and most were diagnosed in FIGO stage I (83.3%). The majority of patients (55.6 %) were treated with complete staging surgery. Additionally, 22.2% were given postoperative chemotherapy. Endometrial cancer was detected in only one case. The mean follow-up period+ SD was 43.11+ 26.02 months. No recurrence of disease was observed in all patients. The estimated 5-year disease-free survival (DFS) was 95% regardless of the stage of the disease. The stage disease slightly influenced disease-free survival. However, no statistical difference between stages (p=0.52). No prognostic factors associated with DFS significantly.Conclusion: The majority of the patients with adult-type granulosa cell tumors of the ovary (AGCTs) presented in the early stage of disease and have an excellent survival rate. Tumor removal procedure with or without complete staging surgery seemed to be the appropriate treatment for granulosa cell tumors. No prognostic factors affecting on disease-free survival rate was found.
Highlights
Granulosa cell tumors of the ovary (GCTs) was first described by Rokitansky [1], are uncommon neoplasm representing 3-5% of all ovarian tumors [2]
GCTs are divided into an adult (AGCT) and juvenile (JGCT) types based on differences in clinical and histopathologic features
adult-type granulosa cell tumors of the ovary (AGCTs) are commonly seen in perimenopausal and postmenopausal women
Summary
Granulosa cell tumors of the ovary (GCTs) was first described by Rokitansky [1], are uncommon neoplasm representing 3-5% of all ovarian tumors [2]. Implied meaning that GCT is derived from the granulosa cell which is a hormonally active cell of the ovarian stroma responsible for estradiol production. GCTs are divided into an adult (AGCT) and juvenile (JGCT) types based on differences in clinical and histopathologic features. The prognostic of these tumors is good when comparing with other epithelial tumors [3]. It is approximately 5% of all GCTs and occurring in premenarchal girls and young women [5]. Patients with juvenile GCT typically present at an early stage with a favorable prognosis. While those presenting with the advanced-stage disease might experience an aggressive clinical presentation
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