Abstract
Objective To explore the clinicopathological characteristics of adult primary intrarenal neuroblastoma. Methods The clinical manifestation, images, histopathological features, and immunohistochemical results were analyzed in one case of adult primary intrarenal neurlblastoma, and the related literatures were reviewed. Results A 54-year-old woman presented with intermittent gross hematuria and left flank pain for 2 mouths. CT revealed left renal carcinoma, left renal vein cancer embolus, and retropefitoneal lymph node metastasis. The tumor was located at the lower left kidney. Histologically, the tumor cells distributed diffusely or flakily, mainly neuroblasts at different developmental stages, with nuclear division, chrysanthemum-shaped mass, neural tube, and neuropil. Immunohistochemical assay showed Vim, GFAP, chromogranin A, NF,S100, and synaptophysin were positively expressed in the tumor cells but CK, CD99, and EMA were not.Conclusions Adult primary renal neuroblastoma is rare and is difficult to be distinguished from renal carcinoma clinically. CT scans and detection of urinary catecholamine metabolites in patients has guiding significance in the diagnosis. Pathological examination is needed to confirm the diagnosis. Key words: Renal tumor; Neuroblastoma; Immunohistochemistry; Clinical pathology
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