Abstract
Pleomorphic Rhabdomyosarcoma (RMS) is a rare form of soft tissue sarcoma in adults. Due to the rarity of adult RMS, information regarding its clinical and biologic characteristics is very limited. I report a case of embryonal RMS of lower extremity involving the right leg peroneal compartment in a 37-year-old man. There was metastasis of the tumor to the ipsilateral inguinal lymph nodes at diagnosis. The patient underwent surgery with enbloc excision of the tumor from the peroneal compartment and ipsilateral inguinal lymphnode biopsy. Histopathological examination revealed high-grade pleomorphic RMS and postoperatively he under went chemotherapy and six cycles of radiotherapy.
Highlights
Rhabdomyosarcoma (RMS) is a highly malignant mesenchymal tumor thought to originate from immature striated muscle
RMSs are rare in adults, with soft-tissue sarcomas making up fewer than 1% of malignancies in adults and RMSs accounting for 3% of all soft tissue sarcomas[1]
Histopathological examination showed a highly cellular tumour with typical features of pleomorphic RMS composed of hyperchromatic pleomorphic cells with areas of large multinucleated tumor giant cells having bizarre nuclei (Figure 3)
Summary
Rhabdomyosarcoma (RMS) is a highly malignant mesenchymal tumor thought to originate from immature striated muscle. It is characterized by the presence of cells having an identifiable striated muscular differentiation with rhabdomyoblasts cells. A 37 years old male driver presented to my office with history of rapidly progressive right leg swelling and pain over a 3 months duration attributed to a football injury. Radiographs of right tibia and fibula showed only soft tissue swelling without bony involvement His blood parameters were within normal range. Histopathological examination showed a highly cellular tumour with typical features of pleomorphic RMS composed of hyperchromatic pleomorphic cells with areas of large multinucleated tumor giant cells having bizarre nuclei (Figure 3). There was no local or systemic recurrence of symptoms with a follow-up of 1 year
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