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Abstract
Adult-onset Still's Disease is a rare auto inflammatory disorder of unknown etiology characterized mainly by high spiking fever, arthritis, evanescent rash and lymphadenopathy. It is a form of systemic onset juvenile rheumatoid arthritis that is encountered in adults, typically between 15-25 years and 36-45years. We here describe a 28 years lady with fever, arthritis of multiple large joints, lymphadenopathy and rash, with negative Rheumatoid factor and evidence of past infection with Ebstein-Barr virus and Parvovirus B19. History, examination findings and investigations showed several features consistent with adult-onset Still's disease along with high ferritin level. After exclusion of probable other diagnosis and use of Yamaguchi criteria, she was diagnosed with adult-onset Still's disease. All the major and minor criteria of Yamaguchi for diagnosis were met. Her disease responded well with steroid, she achieved remission and is currently under maintenance therapy. Keywords: Adult-onset stills disease; arthritis; ferritin; fever.
Highlights
Adult-onset Still’s Disease (AOSD) is a chronic inflammatory disorder characterized by high fever, joint pain and nonpruritic rash
Later in 1971 Bywaters described illness starting in adult life resembling Still’s disease or sero-negative chronic polyarthritis of children.[2]
We here discuss a case of 28 years lady who is diagnosed as AOSD and currently under treatment
Summary
Adult-onset Still’s Disease (AOSD) is a chronic inflammatory disorder characterized by high fever, joint pain and nonpruritic rash. A 28 years lady presented to BPKMCH medical oncology OPD with complaints of fever, pain and swelling of multiple joints, recurrent sore throat and rash since 2 years. Lady recalled history of sore throat 2 years back before the fever and joint pain started, she denied any history of cough, shortness of breath, oral ulcers, photosensitivity or muscle weakness.
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