Abstract
There is paucity of data on non Hodgkin's lymphoma (NHL) from our population in North-East India. In this retrospective study, patients were consecutively followed-up to see the clinic-pathological pattern of NHL, various responses, and pattern of relapses to first line treatment with chemotherapy. All patients in the present study received standard regimen of cyclophosphamde, doxorubicin, vincristine, prednisolone (CHOP) with or without rituximab (R-CHOP) as per our institutional protocol as first line therapy. Our study has shown that, in our adult population, the majority of NHL cases present with stage II and stage III disease and extra nodal involvement, B-cell lymphomas and diffuse large cell lymphomas being the most common subtypes. International prognostic index was a significant factor for varied responses to treatment. The majority of relapses after complete remission occurred in the first year.
Highlights
Non-Hodgkin’s lymphomas (NHL) are the most varied in terms of pathology, clinical aggressiveness, response to treatment and relapse
Patients were consecutively followed-up to see the clinic-pathological pattern of non Hodgkin’s lymphoma (NHL), various responses, and pattern of relapses to first line treatment with chemotherapy
Our study has shown that, in our adult population, the majority of NHL cases present with stage II and stage III disease and extra nodal involvement, B-cell lymphomas and diffuse large cell lymphomas being the most common subtypes
Summary
Non-Hodgkin’s lymphomas (NHL) are the most varied in terms of pathology, clinical aggressiveness, response to treatment and relapse. There is marked variation in these parameters in patients from different geographic regions (Anderson et al, 1998; Smedby, 2006; Dominik et al, 2007; Bofetta, 2011; Zelenetz et al, 2011) These variations were magnified due to the lack of standard protocol for treatment for most part of the last century. There is paucity of both prospective and retrospective studies on Non Hodgkin’s lymphoma from North-eastern part of India, it deserves proper approach. To address these issues, we have tried a retrospective study on patient population from the NorthEastern India
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