Abstract
Lean body mass, as estimated from 40K counting, declines progressively during adult life. The rate of decline tends to speed up in later years, and is somewhat greater in the male. By age 65–70 the average male has 12 Kg. less LBM than at age 25; the female has 5 Kg. less. Longitudinal observations show that this trend is for the most part biological, not secular in origin. The magnitude of the decline is such, and the sex difference in LBM great enough to suggest that age and sex should both be taken into account in such matters as drug dosage and nutritional requirements.
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