Abstract
The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively augmenting or blocking adult hippocampal neurogenesis enhances or impairs discrimination under conditions of high, but not low, interference suggestive of a role in pattern separation. Although contextual discrimination engages population-based coding mechanisms underlying pattern separation such as global remapping in the DG and CA3, how adult hippocampal neurogenesis modulates pattern separation in the DG is poorly understood. Here, we propose a role for adult-born DGCs in re-activation coupled modulation of sparseness through feed-back inhibition to govern global remapping in the DG.
Highlights
The dentate gyrus (DG) of all mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life (Altman and Das, 1965; Kaplan and Hinds, 1977; Cameron et al, 1993; Kuhn et al, 1996; Eriksson et al, 1998; Seri et al, 2001; Knoth et al, 2010; Spalding et al, 2013)
We found that genetically enhancing the number of adult-born DGCs (8 weeks of age and younger) engendered a reduction in spread of voltage sensitive dye (VSD) signal and strength of neuronal activation in the DG
Predictions of how adult hippocampal neurogenesis modulates global remapping in the DG must take into account the extent to which adult-born and developmentally generated DGCs contribute to memory traces or engrams
Summary
The dentate gyrus (DG) of all mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life (Altman and Das, 1965; Kaplan and Hinds, 1977; Cameron et al, 1993; Kuhn et al, 1996; Eriksson et al, 1998; Seri et al, 2001; Knoth et al, 2010; Spalding et al, 2013). Whether 8 weeks old adult-born DGCs exert different levels of feed-back inhibition from that recruited by developmentally generated DGCs remains to be addressed.
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