Adult Granulosa Cell Tumor of the Ovary: A Retrospective Study of 40 Cases

Abstract

Background: Granulosa cell tumors (GCTs) are rare ovarian tumors represent only 5% of all ovarian cancers. GCTs are divided into an adult (AGCT) and juvenile (JGCT) types. The prognosis of these tumors is good when compared with other epithelial tumors. Radical surgery and adjuvant chemotherapy according to the presence of risk factors still the main line of treatment. Many Prognostic factors are suggested to affect the course of the disease like tumor stage and extend of surgery. But due to the small number of cases and indolent course of the disease, clinical characteristics and prognostic factors for this type of tumours still unclear.
 Aim: To determine the clinical characteristics of cases with AGCT and the prognostic factors for disease relapse and survival.
 Methods: This is a retrospective descriptive study. 40 patients with (AGCT) were recruited. Patient characteristics were collected. The disease-free interval and overall survival were determined.
 Results: At the end of the study, the median disease-free survival DFS was 101.215 months (93.2-109.3) with statistically significant difference regarding the stage of the disease, extent of surgery, rupture of the tumor and presence of residual disease. The median overall survival OAS was 106.38 months (100.3-112.5) with statistically significant difference regarding stage of the disease, parity and presence of residual disease.
 Conclusion: (AGCT) are rare tumors with excellent survival. Stage of the disease and extent of surgery were significant prognostic factors affecting the course of the disease. Prospective studies are needed for better understanding of this disease.