Abstract
Adult brainstem gliomas constitute a heterogeneous group of tumors. A better radiological analysis of these tumors will improve their classification and help to better distinguish prognosis subgroups. New MRI techniques may also contribute to differential diagnosis and help neurosurgeons in removing resectable brainstem tumors. However, biopsy remains indicated in many contrast enhancing brainstem masses in adults because of the great variety of differential diagnosis. Conventional radiotherapy is the standard of care of brainstem glioma and chemotherapy has been disappointing to date. Given the lack of efficacy of conventional drugs, a better understanding of the biology of this tumor is the key to develop targeted therapy. In the future, advances in diagnostic and treatment modalities will probably result in improvement in the pattern of care of brainstem gliomas which remain now associated with a poor prognosis.
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