Abstract
Most of the work on culture of atrial and ventricular cardiocytes which was started 75 years ago [1–3] has been done with cells from the hearts of neonates. A study of in vitro growth of an adult animal appeared only in 1974 [4]. In several attempts, isolated cardiomyocytes from adult animals either failed to establish in culture [5–8] or produced cells lacking convincing myotypic properties [9]. Most of the published work up to now has been centered on ventricular cardiocytes, for obvious reasons. In the present review, I shall give a brief description of the techniques used to culture adult atrial cardiocytes and of the ultrastructure, DNA synthetic activity and atrial natriuretic factor (ANF) production of adult atrial cardiocytes in culture.
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