Abstract
AbstractThe interaction of montmorillonite with sotalol hydrochloride (4-(1-hydroxy-N-isopropylaminoethyl) methane sulfanilide) was studied by means of adsorption isotherms, XRD and IR spectroscopy. The amount of sotalol adsorbed depended on pH, the maximum amount adsorbed (0·56 mEq g−1) being considerably less than the exchange capacity of the mineral (0·80 mEq g−1). XRD and IR data revealed that the sotalol is adsorbed into the interlayer space, forming a monolayer complex with a d001 spacing of 17·7 Å, and that the mechanisms involved are cation exchange and ion-dipole interactions. Experiments on the in vitro desorption of the drug from the sotalol-montmorillonite complex indicated that desorption is affected by pH, by the salt concentration of the electrolyte, and by the elimination rate of the desorbed organic cations.
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